| Day | Date | Opponent | Location | TV | Outcome/Time |
| Fri | 11/03/2000 | One World All-Stars(exhibition) | Villanova, Pa. | | 7:00 PM ET
|
| Tue | 11/14/2000 | Fairfield(Preseason NIT) | Villanova, Pa. | | W, 101-85
Recap | Stats | Archived Audio |
| Fri | 11/17/2000 | Preseason NIT-Second Round (Duke) | Durham, N.C. | | L, 98-85
Recap | Stats | Archived Audio |
| Sun | 11/26/2000 | Towson | Villanova, Pa. | | W, 87-75
Recap | Stats | Archived Audio |
| Tue | 11/28/2000 | Alaska-Fairbanks(exhibition) | Villanova, Pa. | | W, 97-70
Recap | Stats |
| Sat | 12/02/2000 | Columbia | Villanova, Pa. | | W, 80-64
Recap | Stats | Archived Audio | Live Box Score |
| Tue | 12/05/2000 | Temple | Villanova, Pa. | CSN | W, 69-62
Recap | Stats | Archived Audio | Live Box Score |
| Mon | 12/11/2000 | St. Joseph's | Philadelphia, Pa. | CN8 | W, 78-75
Recap | Stats | Archived Audio |
| Thu | 12/14/2000 | La Salle | La Salle | | W, 79-72
Recap | Stats | Archived Audio |
| Fri | 12/22/2000 | Fairleigh Dickinson | Villanova, Pa. | | W, 85-63
Recap | Stats | Archived Audio | Live Box Score |
| Thu | 12/28/2000 | Georgia | Georgia | | L, 91-80
Recap | Stats | Archived Audio |
| Sat | 12/30/2000 | St. Francis (PA) | Villanova, Pa. | | W, 92-65
Recap | Stats | Archived Audio | Live Box Score |
| Tue | 01/02/2001 | Rutgers* | Villanova, Pa. | CSN | W, 67-63
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 01/06/2001 | Virginia Tech* | Virginia Tech | ESPN | W, 85-83
Recap | Stats | Archived Audio |
| Tue | 01/09/2001 | Providence* | Villanova, Pa. | | L, 76-67
Recap | Stats | Archived Audio | Live Box Score |
| Sat | 01/13/2001 | UCLA | Los Angeles, CA
(Pauley Pavilion) | CBS | L, 93-65
Recap | Stats | Archived Audio |
| Wed | 01/17/2001 | Virginia Tech* | Villanova, Pa. | | W, 86-74
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Sat | 01/20/2001 | St. John's* | St. John's | WPHL | L, 82-70
Recap | Stats | Archived Audio |
| Wed | 01/24/2001 | Connecticut* | Connecticut | ESPN | W, 70-59
Recap | Stats | Archived Audio |
| Sat | 01/27/2001 | Boston College* | Villanova, Pa. | CSN | L, 90-80
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Wed | 01/31/2001 | Providence* | Providence, R.I. | CN8 | L, 84-64
Recap | Stats | Archived Audio |
| Sun | 02/04/2001 | Boston College* | Chestnut Hill, Mass. | CSN | L, 89-74
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Tue | 02/06/2001 | Pennsylvania | First Union Center
(Philadelphia) | CN8 | W, 80-51
Recap | Stats | Archived Audio |
| Sat | 02/10/2001 | Connecticut* | First Union Center
(Philadelphia) | WPHL | W, 74-60
Recap | Stats | Archived Audio |
| Mon | 02/12/2001 | Georgetown | Washington D.C. | ESPN2 | W, 59-56
Recap | Stats | Archived Audio |
| Sat | 02/17/2001 | Miami* | Villanova, PA | ESPN | L, 80-62
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Tue | 02/20/2001 | West Virginia* | West Virginia | ESPN2 | L, 107-100 (2OT)
Recap | Stats | Archived Audio |
| Sun | 02/25/2001 | St. John's* | Villanova, Pa. | ABC | W, 71-55
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Wed | 02/28/2001 | Seton Hall* | Villanova, Pa. | ESPN | W, 74-55
Recap | Stats | Archived Audio | FANSlive GameTracker |
| Sat | 03/03/2001 | Miami* | Miami Arena | WPHL | L, 65-53
Recap | Stats | Archived Audio |
| Wed | 03/07/2001 | BIG EAST Tournament(West Virginia) | Madison Square Garden | ESPN | W, 82-71
Recap | Stats | Archived Audio |
| Thu | 03/08/2001 | BIG EAST Tournament(Boston College) | Madison Square Garden | ESPN2 | L, 93-79
Recap | Stats | Archived Audio |
| Wed | 03/14/2001 | Minnesota (NIT Tournament) | Minneapolis | | L, 87-78
Recap | Stats | Archived Audio |
